Abnormal Epidermal Keratinization in the repeated epilation mutant mouse
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چکیده
منابع مشابه
Abnormal Epidermal Keratinization in the repeated epilation mutant mouse
Repeated epilation (Er) is a radiation-induced, autosomal, incomplete dominant mutation in mice which is expressed in heterozygotes but is lethal in the homozygous condition. Many effects of the mutation occur in skin: the epidermis in Er/Er mice is adhesive (oral and nasal orifices fuse, limbs adhere to the body wall), hyperplastic, and fails to undergo terminal differentiation. Skin from feta...
متن کاملAbnormal expression and processing of keratins in pupoid fetus (pf/pf) and repeated epilation (Er/Er) mutant mice
The pupoid fetus (pf) and repeated epilation (Er) mutations of mice result in a failure of epidermal differentiation in homozygotes. Expression of the epidermal keratins has been followed in pf/pf and Er/Er mice by two-dimensional gel electrophoresis, and by immunohistochemistry and Western blotting using polyclonal antibodies that are monospecific for individual keratin polypeptides. Our resul...
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A heat-stable protein has recently been isolated from the submaxillary gland of the male mouse which, upon injection, elicits precocious eyelid separation and tooth eruption in the newborn mouse and rat (1). The eyelids of the treated newborn mouse will separate as early as the sixth day after birth, whereas the eyelids of control animals require twelve to thirteen days to separate. The protein...
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Sites of synthesis of sulfur-containing protein in keratinizing epithelium have been studied by radioautography after injection of sulfur-labeled cystine. Bern et al. (3) demonstrated concentration of silver grains immediately below the cornified layer, suggesting that much of sulfur is added at the final stages of keratinization as observed in hair. In contrast, B6langer (4) reported that prot...
متن کاملTissue-specific regulation of junctional communication in the skin of mouse fetuses homozygous for the repeated epilation (Er) mutation.
Mouse embryos homozygous for the repeated epilation (Er) gene have abnormally developed skin characterised by hyper-proliferation and incomplete differentiation of the epidermis. In this report, we have studied the patterns of junctional communication in the skin of these mutants to see if the loss of control of proliferation/differentiation is associated with any altered patterns of communicat...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1982
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.92.2.387